HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Boc-3-hydroxypiperidine → 6-(Piperidin-3-yloxy)isoquinolin-1-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Boc-3-hydroxypiperidine | HCID 545699 | — |
| Reactant | 1-Aminoisoquinolin-6-ol | HCID 135753991 | — |
| Product | 6-(Piperidin-3-yloxy)isoquinolin-1-ylamine | HCID 68874086 | 12.1% |
Reaction Steps
This compound was prepared from racemic 3-hydroxypiperidine-1-carboxylic acid tert-butyl ester (207 mg, 1.02 mmol) and 1-amino-6-hydroxyisoquinoline (198 mg, 1.23 mmol) by the Mitsunobu procedure described in 3C, subsequent Boc deprotection according to procedure described in 3D gave racemic 6-(piperidin-3-yloxy)-isoquinolin-1-ylamine (30 mg), El-MS: m/z=244.4 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618985B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-924bf2b344d240cbbe9021fa5901ce97 |
| Source note | uspto-grants-2009_11 |