Hydrazine hydrate (1:1) → HCID 16222361, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the above (S)-2-[6-(1-benzylpiperidin-3-yloxy)isoquinolin-1-yl]-isoindole-1,3-dione (20 mg, 43 μmol) in ethanol (2 ml) was added hydrazine monohydrate (−3 μL, 65 μmol). The mixture was heated at 50° C. for 2 h then concentrated in vacuo to give a residue. The residue was purified by prep-HPLC to give (S)-6-(1-benzylpiperidine-3-yloxy)isoquinolin-1-yl amine El-MS: m/z=334.3 [M+H]+.

Provenance & Evidence