Potassium Carbonate → 3-(1-Benzoylaminoisoquinolin-6ylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester

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Reaction Steps

Potassium carbonate (44 mg, 0.32 mmol) and 3-methanesulfonyloxypiperidine-1-carboxylic acid tert-butyl ester (70 mg, 0.264 mmol) were added to a solution of the above N-(6-mercaptoisoquinolin-1-yl)-benzamide residue in DMF (2 ml). The mixture was irradiated in a microwave at 160° C. for 600 s then concentrated in vacuo to give a residue. The residue was purified by preparative HPLC to give 3-(1-benzoylaminoisoquinolin-6yl-sulfanyl)piperidine-1--carboxylic acid tert-butyl ester (18 mg), EIMS: m/z=464.3 [M+H]+ and m/z=486.5 [M+Na]+.

Provenance & Evidence