HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1436014Generated: October 26, 2026
Hydrochloric Acid → 5-bromo-6-hydroxy-2H-isoquinolin-1-one
https://huagongshe.com/reaction/1436014
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | 5-Bromo-1-chloro-6-hydroxyisoquinoline | HCID 136337488 | — |
| Product | 5-bromo-6-hydroxy-2H-isoquinolin-1-one | HCID 68872858 | — |
Reaction Steps
5-Bromo-1-chloro-6-hydroxyisoquinoline (108 mg, 0.42 mmol) was mixed with hydrochloric acid (5M, 2 ml) and heated under microwave conditions at 150° C. for 40 minutes. The cooled residue was mixed with methanol and azeotroped to dryness under reduced pressure to give 5-bromo-6-hydroxy-2H-isoquinolin-1-one El-MS: m/z=240 and 242[M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07618985B2 |
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| Source dataset | uspto-grants-2009_11 |
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| ORD ID | ord-6c67a5743af24c3085cab17c36ada983 |
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| Source note | uspto-grants-2009_11 |
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