HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (r/s)-3-(Tert-butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 67242856 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine | HCID 67242904 | — |
Reaction Steps
Intermediate 1 (120 mg) prepared in Step A mentioned above is added with 10% hydrogen chloride/methanol (2 ml, Tokyo Kasei Kogyo), and the mixture is stirred at room temperature for 12 hours. The solvent is concentrated under reduced pressure, and the obtained solid is collected by filtration to obtain the title compound as hydrochloride (84 mg (predictive yield)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618984B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-85bfaa3056bf4e0b80ac403742084e55 |
| Source note | uspto-grants-2009_11 |