HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Boc-amino)piperidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Reactant | 4-Fluoroisoquinoline-5-sulfonylchloride | HCID 11856547 | — |
| Product | Hydrochloric Acid | HCID 313 | 1,222.2% |
| Product | (r/s)-3-(Tert-butoxycarbonyl amino)-1-(4-fluoro-5-isoquinolinesulfonyl)-piperidine | HCID 67242641 | — |
| Product | (r/s)-3-Amino-1-(4-fluoro-5-isoquinolinesulfonyl)piperidine | HCID 67243641 | — |
Reaction Steps
(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-fluoro-5-isoquinolinesulfonyl)-piperidine (Intermediate 17) is prepared from 4-fluoro-5-isoquinolinesulfonyl chloride (172 mg) and 3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method of Example 1, Step A, and then used in the method of Example 1, Step B in a similar manner to obtain the title compound as hydrochloride (156 mg (predictive yield)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618984B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4a3d46b206384cabae7b62300521d7db |
| Source note | uspto-grants-2009_11 |