HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Boc-amino)piperidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Boc-amino)piperidine | HCID 4233041 | — |
| Reactant | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| Product | Hydrochloric Acid | HCID 313 | 1,932.7% |
| Product | 3-(Tert-butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242669 | — |
| Product | (r/s)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67242690 | — |
Reaction Steps
(R/S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)-piperidine (Intermediate 18) is prepared from 4-chloro-5-isoquinolinesulfonyl chloride (183 mg) and 3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method described in Example 1, Step A, and then used in the method of Example 1, Step B in a similar manner to obtain the title compound as hydrochloride (164 mg (predictive yield)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618984B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-126c299982984ca3a1f4790663298875 |
| Source note | uspto-grants-2009_11 |