HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine | HCID 2761404 | — |
| Reactant | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| Reactant | 4-Fluoroisoquinoline-5-sulfonylchloride | HCID 11856547 | — |
| Reactant | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]-1-(4-fluoro-5-isoquinolinesulfonyl)pyrrolidine | HCID 67242681 | — |
Reaction Steps
That is, (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]-1-(4-fluoro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 22a) was prepared by using 4-fluoro-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 31, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 31, Step B in a similar manner to obtain the compound of Example 18-3 as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618984B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-00042accdd0842d3bf0b2a64cef55b4a |
| Source note | uspto-grants-2009_11 |