HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine | HCID 2761404 | — |
| Reactant | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| Reactant | 5-Isoquinolinesulfonyl chloride,1,4-dichloro- | HCID 76851489 | — |
| Reactant | 5-Isoquinolinesulfonyl chloride,4-bromo-1-chloro- | HCID 76851490 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 86613858 | — |
| Product | (S)-1-(1-Hydroxy-4-chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine | HCID 178484869 | — |
Reaction Steps
(S)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 25a) was prepared by using 1,4-dichloro-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 35, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35, Step B in a similar manner to obtain the title compound as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618984B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-a23b4cac50334eae91fcb5272c66bf58 |
| Source note | uspto-grants-2009_11 |