HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | (r/s)-3-(Tert-butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)-pyrrolidine | HCID 67243409 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (r/s)-3-Amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 67242686 | — |
Reaction Steps
Intermediate 28 (30 mg) obtained in Step A mentioned above is added with 10% hydrogen chloride/methanol (4 ml), and the mixture is stirred at room temperature for 20 hours. The solvent is evaporated under reduced pressure to obtain the title compound as hydrochloride (25 mg (predictive yield)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618984B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-64145771ea8e43808e68985d8cdf132d |
| Source note | uspto-grants-2009_11 |