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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1436057Generated: October 31, 2026

3-[n-(Tert-butoxycarbonyl)-n-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine → Hydrochloric Acid

https://huagongshe.com/reaction/1436057

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-[n-(Tert-butoxycarbonyl)-n-methylamino]-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidineHCID 87322379—
Reactant(r/s)-3-(Tert-butoxycarbonyl)amino-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidineHCID 87322862—
ProductHydrochloric AcidHCID 313—
Product(r/s)-1-(1-Amino-4-bromo-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidineHCID 67242682—

Reaction Steps

Intermediate 24 is used in the method of Example 39 instead of Intermediate 26 to obtain the title compound as hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07618984B2
Source datasetuspto-grants-2009_11
ORD IDord-a0bcbca01123446caedaf908b6a1ad78
Source noteuspto-grants-2009_11