反应详情

温度

170 °C

A mixture of 2-[(3,4,5-trifluorobenzyl)amino]ethanol (6.91 g) and diethyl oxalate (20 mL) was stirred at 170° C. for one hour. The reaction solution was concentrated under reduced pressure, and then a diethyl ether was added to the residue. The precipitated crystals were collected by filtration and then air-dried to obtain 7.38 g of the title compound.

1. concentrationThe reaction solution was concentrated under reduced pressure
2. additiona diethyl ether was added to the residue
3. filtrationThe precipitated crystals were collected by filtration
4. customair-dried