Dimethylformamide → HCID 69006026, compound

Participants

Reaction Steps

A mixture of (S)-1-(4-fluorophenyl)ethylamine (5.0 g), chloroacetone (4.78 mL), cesium carbonate (13.9 g), and DMF (50 mL) was stirred at room temperature overnight. The reaction solution was diluted with water and ethyl acetate, and then the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by column chromatography using a silica gel (hexane:ethyl acetate=5:1 to 0:100) to obtain 5.1 g of the title compound.

Provenance & Evidence