HRID1436092

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：[Br-].c1ccc([PH+](c2ccccc2)c2ccccc2)cc1

HCID517696

未命名化合物

结构：O=C1C(O)OC[C@@H]2CCC[C@H](c3ccc(F)cc3)N12

HCID69010340

未命名化合物

PRODUCTS

生成物

结构：O=C1C([P+](c2ccccc2)(c2ccccc2)c2ccccc2)OC[C@@H]2CCC[C@H](c3ccc(F)cc3)N12.[Br-]

HCID86612604

未命名化合物

收率 98.5%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of (6R*,9aS*)-6-(4-fluorophenyl)-3-hydroxyhexahydropyrido[2,1-c][1,4]oxazin-4-one (26 mg) and triphenylphosphonium bromide (40 mg) in acetonitrile (3 mL) was heated under reflux for one hour and 30 minutes. The reaction solution was left to cool to room temperature, and then the solvent was evaporated under reduced pressure to obtain 57 mg of the title compound. The property value of the compound is as follows.

WORKUP

后处理

temperatureunder reflux for one hour and 30 minutes
waitThe reaction solution was left
customthe solvent was evaporated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f5dafab9d2304369a11a48200c245442
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07618960B2
来源说明: uspto-grants-2009_11

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:17]3[C@H:12]([CH2:13][O:14][CH:15](O)[C:16]3=[O:18])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[Br-:20].[C:21]1([PH+:27]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(#N)C>[Br-:20].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]2[N:17]3[C@H:12]([CH2:13][O:14][CH:15]([P+:27]([C:28]4[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=4)([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:16]3=[O:18])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1