Water → HCID 86612606, compound

Participants

Reaction Steps

Diphenylphosphoryl azide (1.0 mL) was added to a solution of 1-(5-chloropyridin-2-yl)ethanol (503 mg) in toluene (8 mL) in a nitrogen atmosphere. The reaction solution was ice-cooled, and 1,8-diazabicyclo[5,4,0]undec-7-ene (0.69 mL) was added dropwise to the solution. The reaction solution was stirred for three hours. Then, the solution was returned to room temperature and stirred overnight. Water and diethyl ether were added to the reaction solution, and the organic layer was separated. The organic layer was dried over magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: hexane-diethyl ether) to obtain 337 mg of the title compound.

Provenance & Evidence