反应详情

To a solution of (R)-6-oxopiperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (CAS No. 183890-36-0, 7.5 g) in THF (200 mL), 3,4,5-trifluorophenylmagnesium bromide (0.35 M solution in diethyl ether, 100 mL) was added dropwise at −40° C., and the reaction solution was stirred at room temperature for six hours. A saturated ammonium chloride solution and ethyl acetate were added to the reaction solution, and the organic layer was separated. The resulting organic layer was dried over magnesium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: heptane->heptane:ethyl acetate=1:1) to obtain 4.0 g of the title compound. The property value of the compound is as follows.

1. customthe organic layer was separated
2. dry with materialThe resulting organic layer was dried over magnesium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography (elution solvent: heptane->heptane:ethyl acetate=1:1)