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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1436132Generated: October 27, 2026

Triphenylphosphine → (Z)-(S)-4-(4-fluorobenzyl)-2-[1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]-6-methylmorpholin-3-one

https://huagongshe.com/reaction/1436132

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriphenylphosphineHCID 11776—
ReactantThionyl ChlorideHCID 24386—
Reactant(S)-4-(4-fluorobenzyl)-2-hydroxy-6-methylmorpholin-3-oneHCID 69005909—
Reactant3-Fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehydeHCID 70700842—
Product(Z)-(S)-4-(4-fluorobenzyl)-2-[1-[3-fluoro-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylidene]-6-methylmorpholin-3-oneHCID 57938669—

Reaction Steps

9.06 mg of the title compound was obtained from (S)-4-(4-fluorobenzyl)-2-hydroxy-6-methylmorpholin-3-one, thionyl chloride, triphenylphosphine, and 3-fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the same manner as in Example 5.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07618960B2
Source datasetuspto-grants-2009_11
ORD IDord-8c99a2c123ae4f7b9c50d66c2611e86d
Source noteuspto-grants-2009_11