Phosphine, triphenyl-, hydrobromide → HCID 16739154, compound

HRID 1436134Notes

Reaction equation

HRID 1436134 reaction equation
[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@@H:4]([N:11]2[CH2:16][C:15]([CH3:18])([CH3:17])[O:14][CH:13](O)[C:12]2=[O:20])[CH2:3][CH2:2]1.[Br-].C1([PH+](C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[F:41][C:42]1[CH:43]=[C:44]([CH:47]=[CH:48][C:49]=1[N:50]1[CH:54]=[C:53]([CH3:55])[N:52]=[CH:51]1)[CH:45]=O>>[O:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@@H:4]([N:11]2[CH2:16][C:15]([CH3:18])([CH3:17])[O:14]/[C:13](=[CH:45]\[C:44]3[CH:47]=[CH:48][C:49]([N:50]4[CH:54]=[C:53]([CH3:55])[N:52]=[CH:51]4)=[C:42]([F:41])[CH:43]=3)/[C:12]2=[O:20])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 517696Phosphine, triphenyl-, hydrobromideHCID 68909251HCID 68909251, compoundHCID 707008423-Fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Product 1

HCID 16739154HCID 16739154, compound

Procedure

25.4 mg of the title compound was obtained from 4-[(S)-chroman-4-yl]-2-hydroxy-6,6-dimethylmorpholin-3-one, triphenylphosphonium bromide, and 3-fluoro-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the same manner as in Example 12.

Sources & evidence

ORD record
ord-e9d3cc0179f34afe87f4ba9250fe879f
Source dataset
uspto-grants-2009_11
Patent number
US07618960B2

Reaction notes

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