HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → (3S)-3-Amino-4-(4-bromophenyl)-1-butanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 1,1-Dimethylethyl {(1S)-1-[(4-bromophenyl)methyl]-3-hydroxypropyl}carbamate | HCID 57594393 | — |
| Product | (3S)-3-Amino-4-(4-bromophenyl)-1-butanol hydrochloride | HCID 67277825 | 94% |
Reaction Steps
1,1-Dimethylethyl {(1S)-1-[(4-bromophenyl)methyl]-3-hydroxypropyl}carbamate (4.4 g, 12.8 mmol) was dissolved in 4N HCl/dioxane (20 mL). After 2 h, the reaction mixture was concentrated in vacuo to give 3.69 g (94%) of the title compound as a white solid. LC/MS (ES) m/e 244.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618981B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-774424e22745405586ea29a5c3a66d6f |
| Source note | uspto-grants-2009_11 |