Diethyl Ether → (S)-3-chloro-N-(4-hydroxy-1-(4-(2-(1-(hydroxyimino)ethyl)-1-methyl-1H-imidazol-4-yl)phenyl)butan-2-yl)-4-isopropoxybenzamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 2 (3.7 g, 11.4 mmol) in THF (40 mL) was added dropwise MeMgBr in Et2O (3M, 11.4 ml, 34.2 mmol) at 0° C. The mixture was stirred at 0° C. for 30 min. The solution was quenched by saturated NH4Cl at 0° C. and diluted between EtOAc and H2O. The organic layer was washed with brine, dried over Na2SO4, filtered and concentrated to give 3 (3.0 g, 94%) without further purification. LRMS (M+H+) m/z 279.0.

Provenance & Evidence