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HRID1436221

反应详情

EQUATION

反应方程式

HRID 1436221 反应方程式

REACTANTS

反应物

2
2,4-dichloroquinazoline 分子结构式
HCID252886

2,4-dichloroquinazoline

C8H4Cl2N2

n-methyl-4-(trifluoromethoxy)aniline 分子结构式
HCID737351

n-methyl-4-(trifluoromethoxy)aniline

C8H8F3NO

PRODUCTS

产物

1
(2-Chloro-quinazolin-4-yl)-(4-trifluoromethoxy-phenyl)-methyl-amine 分子结构式
HCID11164045

(2-Chloro-quinazolin-4-yl)-(4-trifluoromethoxy-phenyl)-methyl-amine

C16H11ClF3N3O

PROCEDURE

实验过程

The title compound was prepared from 2,4-dichloroquinazoline (50 mg, 0.251 mmol) and 4-trifluoromethoxy-N-methylaniline (20 μL, 0.302 mmol) by a procedure similar to example 1b and was isolated as white powder (22 mg, 44%). 1H NMR (CDCl3): 7.93 (dd, J=8.4, and 0.6 Hz, 1H), 7.61 (ddd, J=8.4, 4.5 and 1.2 Hz, 1H), 7.29-7.22 (m, 4H), 7.06 (ddd, J=8.4, 4.5 and 1.2 Hz, 1H), 6.91 (d, J=8.7 Hz, 1H), 3.65 (s, 3H).