3-Methoxyaniline → HCID 22692724, compound

HRID 1436242Notes

Reaction equation

HRID 1436242 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][CH:21]=1)[NH2:18]>>[Cl:1][C:2]1[N:11]=[C:10]([NH:18][C:17]2[CH:19]=[CH:20][CH:21]=[C:15]([O:14][CH3:13])[CH:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 108243-MethoxyanilineHCID 2528862,4-Dichloroquinazoline

Product 1

HCID 22692724HCID 22692724, compound

Procedure

The title compound was prepared from 2,4-dichloroquinazoline and 3-methoxyaniline by a procedure similar to example 28 (80% yield). 1H NMR (CDCl3): 7.79-7.87 (m, 3H), 7.54-7.62 (m, 3H), 7.20-7.35 (m, 3H), 6.76 (dd, J=8.4 and 2.1 Hz, 1H), 3.87 (s, 3H).

Sources & evidence

ORD record
ord-6549c00fc4cd4405bdc44d186d28d50b
Source dataset
uspto-grants-2009_11
Patent number
US07618975B2

Reaction notes

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