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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1436243Generated: October 31, 2026

2-Methoxyaniline → 2-Chloro-N-(2-methoxyphenyl)quinazolin-4-amine

https://huagongshe.com/reaction/1436243

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-MethoxyanilineHCID 7000—
Reactant2,4-DichloroquinazolineHCID 252886—
Product2-Chloro-N-(2-methoxyphenyl)quinazolin-4-amineHCID 22692722—

Reaction Steps

The title compound was prepared from 2,4-dichloroquinazoline and 2-methoxyaniline by a procedure similar to example 28 (35% yield). 1H NMR (CDCl3): 8.76-8.79 (m, 1H), 8.50 (s, broad, 1H), 7.77-7.88 (m, 3H), 7.54-7.59 (m, 1H), 7.09-7.13 (m, 2H), 6.95-6.99 (m, 2H), 4.00 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07618975B2
Source datasetuspto-grants-2009_11
ORD IDord-d3960787c3814d139a98765169fd45a1
Source noteuspto-grants-2009_11