N-Methyl-4-anisidine → HCID 178492248, compound

HRID 1436257Notes

Reaction equation

HRID 1436257 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4](Cl)[N:3]=1.[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([NH:18][CH3:19])=[CH:16][CH:15]=1>>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][NH:8]2)=[C:4]([N:18]([C:17]2[CH:20]=[CH:21][C:14]([O:13][CH3:12])=[CH:15][CH:16]=2)[CH3:19])[N:3]=1

Participants

3

Reactant 2

HCID 22250N-Methyl-4-anisidineHCID 1784188752,6-dichloro-1H-purine

Product 1

HCID 178492248HCID 178492248, compound

Procedure

The title compound was prepared from 2,6-dichloro-9H-purine (50 mg, 0.265) and 4-methoxy-N-methylaniline (40 mg, 0.291 mmol) by a procedure similar to example 1b and was isolated as off white powder (10 mg, 20%). 1H NMR (CDCl3): 7.81 (s, 1H), 7.37 (d, J=8.4 Hz, 2H), 7.04 (d, J=8.4 Hz, 2H), 3.93 (s, 3H), 3.77 (s, 3H).

Sources & evidence

ORD record
ord-fbcde910083940a2abd54b02bb04500b
Source dataset
uspto-grants-2009_11
Patent number
US07618975B2

Reaction notes

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