P-Anisidine → N-(4-Methoxyphenyl)-2-methylquinazolin-4-amine

HRID 1436269Notes

Reaction equation

HRID 1436269 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>>[CH3:12][C:4]1[N:3]=[C:2]([NH:21][C:18]2[CH:19]=[CH:20][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 27854214-Chloro-2-methylquinazoline

Product 1

HCID 42625834N-(4-Methoxyphenyl)-2-methylquinazolin-4-amine

Procedure

The title compound was prepared from 4-chloro-2-methyl-quinazoline (108 mg, 0.605 mmol) and 4-methoxy-phenylamine (89.4 mg, 0.73 mmol) by a procedure similar to Example 72b. 1H NMR (DMSO-d6): 11.28 (brs, 1H), 8.73 (d, J=8.4 Hz, 1H), 8.06 (t, J=7.5 Hz, 1H), 7.85-7.78 (m, 2H), 7.66 (d, J=9 Hz, 2H), 7.06 (d, J=8.7 Hz, 2H), 3.81 (s, 3H), 2.60 (s, 3H).

Sources & evidence

ORD record
ord-4b62bb5cdb754b8a87292435914e8037
Source dataset
uspto-grants-2009_11
Patent number
US07618975B2

Reaction notes

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