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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1436281Generated: November 1, 2026

Methyl iodide → 4-Quinazolinamine, N,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-

https://huagongshe.com/reaction/1436281

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
Reactant2-Methyl-N-(2,4,6-trimethoxyphenyl)quinazolin-4-amineHCID 57938802—
Product4-Quinazolinamine, N,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-HCID 11198562—

Reaction Steps

The title compound was prepared from (2-methyl-quinazolin-4-yl)-(2,4,6-trimethoxy-phenyl)-amine (56 mg, 0.17 mmol) and methyl iodide (0.1 ml, 1.6 mmol) by a procedure similar to example 36. 1H NMR (CDCl3): 7.70 (d, J=8.4 Hz, 1H), 7.49 (t, J=7.8 Hz, 1H), 7.09 (d, J=8.7 Hz, 1H), 6.93 (t, J=8.1 Hz, 1H), 6.18 (s, 2H), 3.86 (s, 3H), 3.63 (s, 6H), 3.44 (s, 3H), 2.70 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07618975B2
Source datasetuspto-grants-2009_11
ORD IDord-f4d15cd1c3d34c7b96a5849eb61b9bd1
Source noteuspto-grants-2009_11