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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1436283Generated: November 1, 2026

4-Ethoxyaniline → 2-Chloro-N-(4-ethoxyphenyl)quinazolin-4-amine

https://huagongshe.com/reaction/1436283

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-EthoxyanilineHCID 9076—
Reactant2,4-DichloroquinazolineHCID 252886—
Product2-Chloro-N-(4-ethoxyphenyl)quinazolin-4-amineHCID 22692729—

Reaction Steps

The title compound was prepared from 2,4-dichloroquinazoline and 4-ethoxyaniline by a procedure similar to example 28 (32%). 1H NMR (CDCl3): 7.81 (m, 1H), 7.65 (m, 1H), 7.32 (m, 2H), 7.03 (m, 1H), 6.73 (m, 3H), 4.09 (q, J=7.2, 2H), 1.49 (t, J=7.2, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07618975B2
Source datasetuspto-grants-2009_11
ORD IDord-d75b4c0042c54c49a320eab602c480d7
Source noteuspto-grants-2009_11