4-Chloro-2-methylquinazoline → N-(2-Fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amine

HRID 1436284Notes

Reaction equation

HRID 1436284 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.[F:13][C:14]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:15]=1[NH2:16]>>[F:13][C:14]1[CH:20]=[C:19]([O:21][CH3:22])[CH:18]=[CH:17][C:15]=1[NH:16][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 27854214-Chloro-2-methylquinazolineHCID 37563832-Fluoro-4-methoxyaniline

Product 1

HCID 42625911N-(2-Fluoro-4-methoxyphenyl)-2-methylquinazolin-4-amine

Procedure

The title compound was prepared from 4-chloro-2-methylquinazoline and 2-fluoro-4-methoxyaniline by a procedure similar to example 28 (79%). 1H NMR (CDCl3): 8.54 (m, 1H), 7.83 (m, 2H), 7.65 (m, 1H), 7.50 (m, 1H), 7.47 (s, broad, 1H), 6.74-6.81 (m, 2H), 3.83 (s, 3H), 2.70 (s, 3H).

Sources & evidence

ORD record
ord-97dc8c7cb6fa4c73a48a49eed31aa55b
Source dataset
uspto-grants-2009_11
Patent number
US07618975B2

Reaction notes

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