4-(Methylamino)benzoic acid → Benzoic acid, 4-[methyl(2-methyl-4-quinazolinyl)amino]-

HRID 1436291Notes

Reaction equation

HRID 1436291 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1.[CH3:13][NH:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=1>>[CH3:13][N:14]([C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=1)[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 663454-(Methylamino)benzoic acidHCID 27854214-Chloro-2-methylquinazoline

Product 1

HCID 11185473Benzoic acid, 4-[methyl(2-methyl-4-quinazolinyl)amino]-

Procedure

The title compound was prepared from 4-chloro-2-methylquinazoline and 4-(methylamino)benzoic acid by a procedure described for example 1b. 1H NMR (CDCl3): 8.42-8.39 (m, 1H), 8.28 (m, 2H), 7.84 (m, 1H), 7.45 (m, 2H), 7.37 (m, 1H), 7.22 (m, 1H), 6.84 (d, J=1H, 8.4), 3.91 (s, 3H), 3.01 (s, 3H).

Sources & evidence

ORD record
ord-87309d86da504e1db4144c0806f3a625
Source dataset
uspto-grants-2009_11
Patent number
US07618975B2

Reaction notes

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