Morpholine → HCID 44193565, compound

Participants

Reaction Steps

A mixture of compound 3 (obtained from example 1) (0.32 g, 1 mmol), morpholine (0.43 g, 5 mmol), and ethanol (30 mL) was refluxed for 4 hrs (TLC monitoring). After removal of solvent in vacuo, the residue was treated with H2O (50 mL). The resulting precipitate was collected and purified by column chromatography (MeOH/CH2Cl2=1:20) to give the title compound 5a (0.28 g, 68% yield). M.p.: 117-118° C.

Provenance & Evidence