Hydrochloric Acid → HCID 131727773, compound

Participants

Reaction Steps

[4-(4-Carbamoyl-3-hydroxy-phenoxy)-3-fluoro-benzyl]-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-1e-1: 15 g) was dissolved in 150 mL of dichloromethane and treated with 50 mL of a 4.0 M hydrogen chloride solution in dioxane. After stirring 24 hours at room temperature, the volatiles were removed under reduced pressure and the resulting crude material was suspended in methanol, heated at reflux for 20 minutes, and stirred overnight at room temperature. The resulting slurry was collect via filtration, rinsed with chilled methanol, and dried under vacuum to provide the title compound (1A).

Provenance & Evidence