HCID 11206170, compound → Menthol

Participants

Reaction Steps

The reaction was conducted in the same manner as in Example 10 except that methanol was used instead of the solvent and the reaction time was altered to 2 hours. The obtained reaction solution was analyzed by GC, to find that 12% of the menthyl vinyl ether was left with an optical purity of 76% ee. Further, the reaction solution was purified by silica gel column chromatography to obtain the reaction product menthol in a yield of 88%. Also, the kre1 value showing the selectivity of reactions at this time was 2.3.

Provenance & Evidence