4-(2,2,2-Trifluoroethoxy)benzonitrile → HCID 67500259, compound

HRID 1436340Notes

Reaction equation

HRID 1436340 reaction equation
F[C:2](F)(F)[CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=1.FC(F)(F)CO[C:20]1[CH:27]=CC(C#N)=C[CH:21]=1>>[CH:3]1([O:4][C:5]2[N:10]=[CH:9][C:8]([CH:11]([NH2:13])[CH3:12])=[CH:7][CH:6]=2)[CH2:27][CH2:20][CH2:21][CH2:2]1

Participants

3

Reactant 2

HCID 109545944-(2,2,2-Trifluoroethoxy)benzonitrileHCID 586291003-Pyridinemethanamine, alpha-methyl-6-(2,2,2-trifluoroethoxy)-

Product 1

HCID 67500259HCID 67500259, compound

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 1-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]ethanamine, step B, starting from 4-(2,2,2-trifluoroethoxy)benzonitrile. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.28-7.34 (m, 2 H) 6.94-7.00 (m, 2 H) 4.70 (q, J=8.78 Hz, 2 H) 3.95 (q, J=6.53 Hz, 1 H) 1.21 (d, J=6.78 Hz, 3 H). MS (ESI) m/z: 220 [M+H]

Sources & evidence

ORD record
ord-918f17d928464ea7bb79fa00fd5977ee
Source dataset
uspto-grants-2009_11
Patent number
US07618993B2

Reaction notes

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