Triethylamine → HCID 57939120, compound

Participants

Reaction Steps

Acryloylchloride (0.27 g, 3.0 mmol) is added dropwise and below 20° C. to a solution of 0.98 g (1.5 mmol) of 2-(2,6-Diethyl-4-hydroxy-2,3,6-trimethyl-piperidin-1-yloxy)-N-{6-[2-(2,6-diethyl-4-hydroxy-2,3,6-trimethyl-piperidin-1-yloxy)-propionylamino]-hexyl}-propionamide (prepared as described in WO 03/004471 A1, example A3) and 0.3 g (3.0 mmol) triethylamine in 30 ml ethyl acetate. The mixture is stirred for 12 h at room temperature, then washed with 3×10 ml water, dried over Na2SO4 and evaporated. Chromatography of the residue over silica gel with hexane-ethyl acetate (3:2) afford 0.33 g of the title compound as a viscous slightly yellow oil.

Provenance & Evidence