Ethyl Acetate → HCID 25028721, compound

Participants

Reaction Steps

In the same manner as described in step 4 of Example 1, replacing (2R)-2-{[4-(4-bromophenyl)-1,3-thiazol-2-yl]amino}propan-1-ol with 2-[4-(4-bromo-phenyl)-thiazol-2-ylamino]-butan-1-ol, prepared in the previous step, and purification by flash chromatography using a solvent gradient of 10 to 20% ethyl acetate in hexane gave the title compound (155 mg, 72%) as a white solid; mp 148.5° C.; MS (ESI) m/z 353 [M+H]+. Anal. Calcd for C14H13BrN2O2S: C, 47.60; H, 3.71; N, 7.93. Found: C, 47.25; H, 3.64; N, 7.74. HRMS: calcd for C14H13BrN2O2S+H+, 352.99538; found (ESI, [M+H]+), 352.9939.

Provenance & Evidence