Ethyl Acetate → HCID 25029709, compound

Participants

Reaction Steps

In the same manner as described in step 4 of Example 1, replacing (2R)-2-{[4-(4-bromophenyl)-1,3-thiazol-2-yl]amino}propan-1-ol with 2-{[4-(4-bromophenyl)-1,3-thiazol-2-yl]amino}propan-1-ol, prepared in the previous step, and purification by flash chromatography using a solvent gradient of 10 to 30% ethyl acetate in hexane gave the title compound (293 mg, 64%) as a white solid; mp 189-190° C.; MS (ESI) m/z 339 [M+H]+. Anal. Calcd for C13H11BrN2O2S: C, 46.03; H, 3.27; N, 8.26. Found: C, 45.83; H, 3.25; N, 8.07. HRMS: calcd for C13H, BrN2O2S+H+, 338.97973; found (ESI, [M+H]+), 338.9784.

Provenance & Evidence