反应详情

A mixture of 2,4′-dibromopropiophenone (3.940 g, 13.5 mmol) and N-(2-hydroxy-1,1-dimethylethyl)thiourea (2.000 g, 13.5 mmol), prepared in step 2 of Example 52, in 80 mL of absolute ethanol was refluxed under nitrogen for 3 h. The solvent was removed under reduced pressure to give 2-{[4-(4-bromophenyl)-5-methyl-1,3-thiazol-2-yl]amino}-2-methylpropan-1-ol hydrobromide (5.717 g, 100%) as a tan oil, MS (ESI) m/z 341.

1. temperaturewas refluxed under nitrogen for 3 h
2. customThe solvent was removed under reduced pressure