2-Amino-2-methyl-1-propanol → 2-{[4-(4-Bromo-2-fluorophenyl)-1,3-thiazol-2-yl]amino}-2-methylpropan-1-ol

Participants

Reaction Conditions

Reaction Steps

2-Bromo-4-(4-bromo-2-fluorophenyl)-1,3-thiazole (1.5 g, 4.4 mmol), prepared in the previous step, and 2-amino-2-methyl-1-propanol (2.5 mL, 26.7 mmol) were placed in a sealed tube and heated to 175° C. overnight. The reaction was concentrated under reduced pressure. The residue was purified on silica gel using a stepwise gradient of 5-40% ethyl acetate:hexane to give 2-{[4-(4-bromo-2-fluorophenyl)-1,3-thiazol-2-yl]amino}-2-methylpropan-1-ol (0.3 g, 22%), MS (ES) m/z 346 [M+H]+.

Provenance & Evidence