Isothiocyanatopotassium → 1-(4-Chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone

HRID 1436450Notes

Reaction equation

HRID 1436450 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([F:12])[CH:6]=1)=[O:4].[N-:13]=[C:14]=[S:15].[K+]>C(O)C>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][S:15][C:14]#[N:13])=[CH:6][C:7]=1[F:12]

Participants

4

Reactant 2

HCID 10931372IsothiocyanatopotassiumHCID 230032952-Bromo-1-(4-chloro-3-fluorophenyl)ethanone

Product 1

HCID 866186171-(4-Chloro-3-fluoro-phenyl)-2-thiocyanato-ethanoneYield 100.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same manner as described in step 4 of Example 78, using 2-bromo-1-(4-chloro-3-fluoro-phenyl)-ethanone (2.7 g, 10.7 mmol), prepared in the previous step, and potassium isothiocyanate (1.25 g, 12.8 mmol) in ethanol (150 mL) the crude product was collected by suction filtration to give 1-(4-chloro-3-fluoro-phenyl)-2-thiocyanato-ethanone (2.47 g, 100%), which was used in the next step without further purification. MS (ES) m/z 230[M+H+].

Workup

  1. filtrationwas collected by suction filtration

Sources & evidence

ORD record
ord-7e06f8fe6fc743dfb43f3131c67df4b5
Source dataset
uspto-grants-2009_11
Patent number
US07618990B2

Reaction notes

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