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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 143647Generated: October 26, 2026

Tetrahydrofuran → 2-(3,5-Bis-trifluoromethyl-phenyl)-3-(2,4-dichloro-pyrimidin-5-yl)-propionic acid methyl ester

https://huagongshe.com/reaction/143647

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantEthyl AcetateHCID 8857—
ReactantCyclohexylisopropylamineHCID 62386—
ReactantMethyl 2-[3,5-bis(trifluoromethyl)phenyl]acetateHCID 10401718—
Reactant2,4-Dichloro-5-(iodomethyl)pyrimidineHCID 21939352—
ReactantButyllithiumHCID 178418339—
Product2-(3,5-Bis-trifluoromethyl-phenyl)-3-(2,4-dichloro-pyrimidin-5-yl)-propionic acid methyl esterHCID 21044323—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-394153bbd7324235b55f9233a0ae3297
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)