Bis-(1H-imidazol-2-YL)-methanone → HCID 25007104, compound

Participants

Reaction Conditions

Reaction Steps

A portion of 4-[4-(4-Bromo-phenyl)-thiazol-2-ylamino]-cyclohexanecarboxylic acid (50 mg, 0.13 mmol) was dissolved in dioxane (10 mL). Carbonyl diimidazole (26 mg, 0.16 mmol) was added and the mixture was heated to 100° C. for 16 h. The mixture was concentrated and chromatographed with 10% acetone in hexane to give 32 mg of 2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-azabicyclo[2.2.2]octan-3-one.

Provenance & Evidence