(2-Aminopyrimidin-5-yl)boronic acid → 5-(6-((4-(Methylsulfonyl)piperidin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidin-2-yl)pyrimidin-2-amine

HRID 143652Notes

Reaction equation

HRID 143652 reaction equation
[Cl:1][c:2]1[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([S:18](=[O:19])(=[O:20])[CH3:21])[CH2:16][CH2:17]1)[cH:10]2.[NH2:28][c:29]1[n:30][cH:31][c:32]([B:35]([OH:36])[OH:37])[cH:33][n:34]1>>[c:2]1(-[c:32]2[cH:31][n:30][c:29]([NH2:28])[n:34][cH:33]2)[n:3][c:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH2:11][N:12]1[CH2:13][CH2:14][CH:15]([S:18](=[O:19])(=[O:20])[CH3:21])[CH2:16][CH2:17]1)[cH:10]2

Participants

3

Reactant 2

HCID 17750211(2-Aminopyrimidin-5-yl)boronic acidHCID 866235382-Chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[2,3-d]pyrimidine

Product 1

HCID 568335445-(6-((4-(Methylsulfonyl)piperidin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidin-2-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-f3e376bb652743f4ab6c366756e1022c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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