HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Cyclopropylamino-6-(methanesulfonyl-methylamino)-isonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Cyclopropylamino-6-(methanesulfonyl-methylamino)-isonicotinic acid methylester | HCID 68818381 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Cyclopropylamino-6-(methanesulfonyl-methylamino)-isonicotinic acid | HCID 68814545 | 91% |
Reaction Steps
Treat a solution of 2-cyclopropylamino-6-(methanesulfonyl-methylamino)-isonicotinic acid methyl ester (261 mg, 0.87 mmol) in methanol (8 mL) with 1 N NaOH (1.3 mL, 1.31 mmol) at room temperature. Stir for 5 h, acidify with 1 N HCl to about pH=3. Extract the reaction mixture with ethyl acetate, dry (sodium sulfate) and concentrate to give the title compound (226 mg, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618978B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-ac02c5f53ec9488398afcc8cd999524f |
| Source note | uspto-grants-2009_11 |