HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-sec-Butylamino-6-methanesulfonyloxy-isonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 2-sec-Butylamino-6-methanesulfonyloxy-isonicotinic acid methyl ester | HCID 86615011 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-sec-Butylamino-6-methanesulfonyloxy-isonicotinic acid | HCID 86615012 | — |
Reaction Steps
Add 1 N lithium hydroxide (2 mL) to a solution of 2-sec-butylamino-6-methanesulfonyloxy-isonicotinic acid methyl ester (235 mg, 0.743 mmol) in THF (15 mL) at 0° C. Warm to room temperature and stir for 12 h. Acidify with 5% aqueous HCl to about pH=3, extract with ethyl acetate, dry (magnesium sulfate), and concentrate to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618978B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-02d37223f98c464c9fce56ded617f9ee |
| Source note | uspto-grants-2009_11 |