HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 3-Ethylcarbamoyl-5-(methyl-propylcarbamoyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Ethylcarbamoyl-5-(methyl-propylcarbamoyl)-benzoic acid ethyl ester | HCID 68815039 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Ethylcarbamoyl-5-(methyl-propylcarbamoyl)-benzoic acid | HCID 68817338 | 74% |
Reaction Steps
Stir a solution of 3-ethylcarbamoyl-5-(methyl-propylcarbamoyl)-benzoic acid ethyl ester (157 mg, 0.5 mmol), 1 N aqueous lithium hydroxide (2.45 mL, 2.45 mmol) and THF (2.45 mL) at room temperature overnight. Dilute the reaction with water and extract with dichloromethane. Acidify the aqueous with 5 N HCl , extract the aqueous with dichloromethane and dry (magnesium sulfate) and concentrate to give the title compound (106 mg, 74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618978B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-1f80e735611a41dd8ab948e34044b5cd |
| Source note | uspto-grants-2009_11 |