Lithium Hydroxide → HCID 68817904, compound

Participants

Reaction Steps

Stir a solution of 5-difluoromethyl-N-methyl-N-propyl-isophthalarnic acid ethyl ester (68 mg, 0.23 mmol), 1 N lithium hydroxide (1.15 mL) and THF (1.15 mL) at room temperature over the weekend. Add water and extract with dichloromethane. Acidify the aqueous with 5 N HCl (240 μL), extract with dichloromethane, dry (magnesium sulfate) and concentrate to give the title compound (61 mg, 100%).

Provenance & Evidence