反应详情

Heat a solution of 5-formyl-N-methyl-N-propyl-isophthalamic acid ethyl ester (300 mg, 1.08 mmol), tosylmethyl isocyanide (254 mg, 1.3 mmol), and sodium methoxide (193 mg, 3.57 mmol) in methanol (3.1 mL) at 40° C. for 1 h. Add water to the hot solution and extract with dichloromethane and ethyl acetate. Acidify the aqueous with 5 N HCl, extract with dichloromethane, dry (magnesium sulfate), concentrate and purify (silica gel chromatography, eluting with 0:100 to 4:96 methanol:dichloromethane) to give the title compound (203 mg, 65%).

1. extractionAdd water to the hot solution and extract with dichloromethane and ethyl acetate
2. extractionextract with dichloromethane
3. dry with materialdry (magnesium sulfate)
4. concentrationconcentrate
5. custompurify
6. wash(silica gel chromatography, eluting with 0:100 to 4:96 methanol:dichloromethane)