HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(Methanesulfonyl-methylamino)-N-methyl-N-propyl-isophthalamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(Methanesulfonyl-methylamino)-N-methyl-N-propyl-isophthalamic acid methyl ester | HCID 68815370 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-(Methanesulfonyl-methylamino)-N-methyl-N-propyl-isophthalamic acid | HCID 21062059 | — |
Reaction Steps
Dissolve 5-(methanesulfonyl-methylamino)-N-methyl-N-propyl-isophthalamic acid methyl ester (1.09 g, 3.18 mmol) in THF (80 mL) and add 1 N NaOH (16 mL, 16 mmol). Stir at room temperature for 16 h and add 5 N HCl (5 mL). Dilute with ethyl acetate, wash with saturated aqueous sodium chloride, dry (magnesium sulfate) and concentrate to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618978B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-ac3617e84a004362bf0064d6200f373c |
| Source note | uspto-grants-2009_11 |