HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 68814471, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-hydroxymethyl-N-methyl-N-propyl-isophthalamic acid ethyl ester | HCID 68816479 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 68814471 | HCID 68814471 | — |
Reaction Steps
Stir 5-hydroxymethyl-N-methyl-N-propyl-isophthalamic acid ethyl ester (1.1 g, 3.9 mmol) in THF (20 mL). Add sodium hydride (0.78 g, 60% in mineral oil) and iodomethane (729 μL, 11.7 mmol). Stir at room temperature for 3 h. Concentrate to give the title product which is used directly in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618978B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-33c2ddff15914d24be9d4bef8f31f231 |
| Source note | uspto-grants-2009_11 |