HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 5-Nitro-N,N-dipropyl-isophthalamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 3-[(dipropylamino)carbonyl]-5-nitrobenzoate | HCID 690570 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Nitro-N,N-dipropyl-isophthalamic acid | HCID 68818217 | 92% |
Reaction Steps
Dissolve 5-nitro-N,N-dipropyl-isophthalamic acid methyl ester (1.000 g, 3.243 mmol) and lithium hydroxide (0.089 g, 3.730 mmol) in a mixture of THF (3.16 mL), water (1.58 mL) and methanol (1.58 mL). Stir the mixture at room temperature until the starting material is consumed. Concentrate and acidify with 1 N HCl. Extract with ethyl acetate, dry (magnesium sulfate) and concentrate to give the title compound (0.874 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618978B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-0de086e20c44463cbb3605981c5521b4 |
| Source note | uspto-grants-2009_11 |